Specific inhibition of skeletal α-actin gene transcription by applied mechanical forces through integrins and actin
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چکیده
منابع مشابه
Specific inhibition of skeletal alpha-actin gene transcription by applied mechanical forces through integrins and actin.
Skeletal alpha-actin (skA), a prominent fetal actin isoform that is re-expressed by adult cardiac myocytes after chronic overload in vivo, provides a model for studying cytoskeletal gene regulation by mechanical forces in vitro. We have determined the mechanisms by which perpendicular applied forces acting through integrins and the actin cytoskeleton regulate the expression of skA. Rat-2 fibrob...
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ژورنال
عنوان ژورنال: Biochemical Journal
سال: 1999
ISSN: 0264-6021,1470-8728
DOI: 10.1042/bj3410647